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Progesterone (17-OH) EIA | | | General Information | |
| Vendor | | ALPCO Diagnostics | | Item | | Progesterone (17-OH) EIA | | Catalog Number | | 20-DR-1292 | | Size | | 96 Wells | | Range | | 0.15 - 20 ng/ml | | Sample Type | | Serum | | Regulatory Status | | For In-Vitro Diagnostic Use | | Discipline | | Reproductive Hormones | | Sensitivity | | 0.05 ng/ml | | Incubation Time | | 1 hr and 35 min | | Pricing |  | Inquire |
| | Product Description | |
| The steroid 17a Hydroxyprogesterone (17aOHP) is produced by both the adrenal cortex and gonads. Even
though 17aOHP has relatively little progestational activity, it is of intense clinical interest because it is the
immediate precursor to 11-desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17aOHP,
measurement of 17aOHP is a useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase
deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17aOHP is secreted in abundant
excess. It is moderately elevated in the 11ß-hydroxylase deficiency as well. Measurement of 17aOHP is
therefore valuable in the initial diagnosis of CAH. The 17aOH Progesterone ELISA KIT is based on the competition principle and the microplate separation. An
unknown amount of 17aOHP present in the sample and a fixed amount of 17aOHP conjugated with horseradish
peroxidase compete for the binding sites of a polyclonal 17aOHP antiserum coated onto the wells. After
one hour incubation the microtiterplate is washed to stop the competition reaction. Having added the substrate
solution the concentration of 17aOHP is inversely proportional to the optical density measured. | |
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