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	Genetic Analysis Systems in the Clinical Mainstream

> > > Calcitonin, Ultra-Sensitive RIA Test

Calcitonin, Ultra-Sensitive RIA Test

General Information

Vendor		Diagnostic Systems Laboratories, Inc.
Item		Calcitonin, Ultra-Sensitive RIA Test
Catalog Number		DSL-5200
Size		100 Tubes
Range		8, 5 - 500 pg/mL
Sample Type		Serum, Plasma
Regulatory Status		For In Vitro Diagnostic Use
Discipline		Double Antibody RIA
Sensitivity		3.5 pg/mL
Incubation Time		2 x 20-24 hrs at 2-8C + 15 mins at RT
Pricing		Inquire

Product Description

Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in decreased mobilization of calcium from bone [1]. This effect is most evident in conditions associated with high levels of bone remodeling (e.g. in Pagets disease) following exogenous administration of calcitonin. Exogenously administered calcitonin has also been shown to reduce pain associated with Pagets disease and malignancy, apparently by a direct effect on the central nervous system. Calcitonin secretion is stimulated by increased plasma calcium concentrations, and is also regulated by gastrointestinal peptides, estrogens and vitamin D. Gastric peptide stimulation of calcitonin secretion following a meal may play a role in maintaining postprandial calcium homeostasis. Abnormally elevated levels of calcitonin are characteristic of thyroid C-cell hyperplasia and medullary thyroid carcinoma [2,3]. Elevated serum calcitonin levels may also occur in a variety of other malignancies, possibly due to ectopic calcitonin production [4].

Copp DH. Endocrinology 131:1007-1008, 1992.
McLean GW, et al. Metabolism 33:790-796, 1984.
Saad MF, et al. Medicine 63:319-342, 1984.
Schwartz KE, et al. J Clin Endocrinol Metab 49:438-444, 1979.

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