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DHT RIA Test | | | General Information | |
| Vendor | | Diagnostic Systems Laboratories, Inc. | | Item | | DHT RIA Test | | Product Number | | DSL-9600 | | Size | | 100 tubes | | Range | | 8, 25 - 2500 pg/mL | | Sample Type | | Serum, Plasma | | Regulatory Status | | For Research Use Only within North America | | Sensitivity | | 4 pg/mL | | Incubation Time | | 2 hrs on shaker at RT | | Storage / Stability | | 12 wks | | Sample Size | | 100 µL Extracted Samples | | Pretreatment | | Oxidation followed by extraction | | Format / Method | | Coated Tube RIA | | Pricing |  | Inquire | | Financing | | To finance this purchase click here (U.S. customers only) |
| | Product Description | |
| 5a-Dihydrotestosterone (DHT) is a potent naturally occurring androgen produced from testosterone through the action of cholestenone 5a-reductase [1]. The concentrations of 5a-reductase are highest in certain peripheral tissues, including genital skin and hair follicles, and are localized intra-cellularly in apparent association with the nuclear membrane. DHT exerts its biological action by intracellular binding to the androgen receptor; and this complex is then transferred to the nucleus where DNA-binding occurs with resultant effects on DNA transcription [2]. Most of the residual DHT undergoes intracellular metabolism to 3a -androstanediol and 3a -androstanediol glucuronide. Only a small proportion of DHT escapes into the peripheral circulation, where it is present primarily complexed to sex-hormone binding globulin [3].
In fetal life, testosterone causes virilization of the Wolffian ducts while DHT is responsible for the development of the male external genitalia and prostate. During male sexual maturation, DHT is primarily responsible for the physical changes
An autosomal-recessive genetic deficiency of 5 a -reductase, referred to as male pseudo-hermaphroditism or pseudo-vaginal perineoscrotal hypospadias leads to inadequate differentiation of DHT-dependent peripheral tissues. Male infants with this disorder have ambiguous genitalia and are often raised as females, although significant virilization may occur later in life presumably due to the natural increase in testosterone levels [2].
- Miller WL: Molecular biology of steroid hormone synthesis. Endocrin Rev 9:295-318, 1988.
- Pang S, Riddick L: Hirsutism. IN Lifshitz F: Pediatric Endocrinology, A Clinical Guide, second edition. Marcel Dekker, New York, 1990, pp. 259-291.
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| Diagnostic Systems Laboratories, Inc. | | Customer Service: (800) 231-7970 | | Web site: http://www.dslabs.com | | Please mention Medcompare.com when you contact the vendor. |
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