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Cortisol RIA Test | | | General Information | |
| Vendor | | Diagnostic Systems Laboratories, Inc. | | Item | | Cortisol RIA Test | | Catalog Number | | DSL-2100-5 | | Size | | 500 tubes | | Range | | 7, 0.5 - 60 µg/dL | | Sample Type | | Serum, Plasma, Urine | | Regulatory Status | | For In Vitro Diagnostic Use | | Discipline | | Coated Tube RIA | | Sensitivity | | 0.3 µg/dL | | Incubation Time | | 45 mins at 37C | | Pricing |  | Inquire |
| | Product Description | |
| Cortisol is the most potent glucocorticoid produced by the human adrenal cortex. In plasma, most cortisol is bound with high affinity to corticosteroid-binding globulin (CBG), with the remainder loosely bound to albumin. Cortisol acts on specific intracellular receptors with effects in numerous physiologic systems, including immune function, glucose counter-regulation, vascular tone, substrate utilization and bone metabolism [1,2,3]. Cortisol is excreted in urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of ACTH and cortisol are also secreted independently of the circadian rhythm in response to physical and psychological stress [4,5]. Elevated cortisol levels and lack of diurnal variation have been identified in patients with Cushings disease (ACTH hypersecretion) [2,6]. Elevated circulating cortisol levels have also been identified in patients with adrenal tumors [7]. Low cortisol levels are found in conditions of primary adrenal insufficiency and in ACTH deficiency [1,2,8,9].
References
- Drucker S & New MI. Pediatr Clin North Am 34:1055-1066, 1987.
- Migeon CJ & Lanes RL: Adrenal cortex: hypo- and hyperfunction. IN Lifshitz F (ed): Pediatric Endocrinology, A Clinical Guide, 2nd ed. Marcel Dekker, Inc., New York, 1990, pp. 333-352.
- Hyams JS & Carey DE. J Pediatr 113:249-254, 1988.
- Kreiger DT. J Steroid Biochem 6:785-791, 1975.
- Chernow B, et al. Arch Intern Med 147:1273-1278, 1987.
- Crapo L. Metabolism 28:955-977, 1979.
- Lee PDK, et al. Pediatrics 76:437-444, 1985.
- Leisti S, et al. Pediatr Res 17:861-867, 1983.
- Alsever RN & Gotlin RW: Handbook of Endocrine Tests in Adults and Children, 2nd ed. Year Book Medical Publishers, Inc., Chicago, 1978.
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| Diagnostic Systems Laboratories, Inc. | | Customer Service: (800) 231-7970 | | Web site: http://www.dslabs.com | | Please mention Medcompare.com when you contact the vendor. |
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