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DHEA RIA Test | | | General Information | |
| Vendor | | Diagnostic Systems Laboratories, Inc. | | Item | | DHEA RIA Test | | Catalog Number | | DSL-9000-5 | | Size | | 500 tubes | | Range | | 6, 0.2 - 30 ng/mL | | Sample Type | | Serum, Plasma | | Regulatory Status | | For In Vitro Diagnostic Use | | Discipline | | RIA | | Sensitivity | | 0.02 ng/mL | | Incubation Time | | 2 hrs at 37C | | Pricing |  | Inquire | | Financing | | To finance this purchase click here (U.S. customers only) |
| | Product Description | |
| Dehydroepiandrosterone (DHEA) is produced in the adrenal cortex and, to a lesser extent, the gonads [1,2,3]. DHEA serves as a precursor in testosterone and estrogen synthesis, and has relatively weak androgenic activity, estimated at ~10% that of testosterone [1]. However, in neonates, peripubertal children and in adult women, DHEA is an important androgen as circulating DHEA levels may be several-fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgens (androstenedione and testosterone) and estrogens may occur. In addition, DHEA has a relatively low affinity for sex-hormone binding globulin. DHEA is rapidly cleared from the circulation compared to the sulfated conjugate, DHEA-S.
Measurement of serum DHEA is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in hypoadrenalism, while elevated levels occur in several conditions including virilizing adrenal adenoma and carcinoma, 21-hydroxylase and 3ß-hydroxysteroid dehydrogenase deficiencies and in some cases of female hirsutism [3]. Because very little DHEA is produced by the gonads, measurement of DHEA levels may aid in the localization of androgen source in virilizing conditions.
- Dorfman RI, Shipley RA: Androgens. John Wiley and Sons, New York, 1956, pp. 116-128.
- Meikle AW, et al. Endocrinol Metab Clin North Am 20:381-400, 1991.
- Pang S & Riddick L: Hirsutism. IN Lifshitz F (ed): Pediatric Endocrinology, A Clinical Guide, second edition. Marcel Dekker, Inc., New York, 1990, pp. 259-291.
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| Diagnostic Systems Laboratories, Inc. | | Customer Service: (800) 231-7970 | | Web site: http://www.dslabs.com | | Please mention Medcompare.com when you contact the vendor. |
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