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PAPP-A, Ultra-Sensitive ELISA Test | | | General Information | |
| Vendor | | Diagnostic Systems Laboratories, Inc. | | Item | | PAPP-A, Ultra-Sensitive ELISA Test | | Features | | Inquire | | Approval | | For Research Use Only within North America | | Product Number | | DSL-10-27200 | | Size | | 96 wells | | Range | | 6, 0.45 - 100 µIU/mL | | Sample Type | | Serum | | Sensitivity | | 0.06 µIU/mL | | Incubation Time | | 2 hrs + 1 hr + 10 mins on shaker at RT | | Storage / Stability | | 18 mths | | Sample Size | | 50 µL | | Pretreatment | | None | | Format / Method | | Coated Well ELISA | | Pricing |  | Inquire |
| | Product Description | |
| Pregnancy-associated plasma protein A (PAPP-A) is a large placenta-derived glycoprotein [1]. PAPP-A is produced in high concentrations by placental trophoblast cells, and is released into the maternal circulation in increasing concentrations throughout gestation until delivery [1]. PAPP-A is not specific to pregnancy since measurable levels have been found in non-pregnant females and in males. [2]. The biological role of PAPP-A is unknown, however, it has been suggested that PAPP-A may serve as an important growth regulatory factor. It has been shown that PAPP-A
specifically proteolyses insulin-like growth factor binding protein-4 (IGFBP-4), thereby regulating local IGF bioavailability and mitogenic effectiveness [3].
- Qin Q-P, et al. Clin Chem 43: 2323-2332, 1997
- Bischof P, et al. Arch Gynecol. 273: 109-116, 1986
- Conover CA et al. Development. 131(5):1187-1194, 2004
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| Diagnostic Systems Laboratories, Inc. | | Customer Service: (800) 231-7970 | | Web site: http://www.dslabs.com | | Please mention Medcompare.com when you contact the vendor. |
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