|
|
 |
Renin IRMA Test | | | General Information | |
| Vendor | | Diagnostic Systems Laboratories, Inc. | | Item | | Renin IRMA Test | | Features | | Inquire | | Approval | | For In Vitro Diagnostic Use | | Product Number | | DSL-25100 | | Size | | 100 tubes | | Range | | 5, 5 - 500 pg/mL | | Sample Type | | Serum, Plasma | | Sensitivity | | 0.48 pg/mL | | Incubation Time | | 3 hrs on shaker at RT | | Storage / Stability | | 8 wks | | Sample Size | | 200 µL | | Pretreatment | | None | | Format / Method | | Coated Bead IRMA | | Pricing |  | Inquire |
| | Product Description | |
| Renin, a protease secreted by the kidney, plays a vital role in the renin-angiotensin system. The renin-angiotensin system regulates blood pressure, and controls water and electrolyte retention by the kidney. Renin is secreted in response to several factors including decreased intravascular volume and decreased plasma sodium and chloride concentration. Renin acts by converting the renin-substrate (angiotensinogen) to angiotensin I in the blood. Angiotensin I has no physiologic activity but is subsequently converted to angiotensin II in the vascular epithelium of the lung. Angiotensin II is a potent pressor agent acting either directly or via the central nervous system to cause vasoconstriction. In addition, angiotensin II stimulates aldosterone secretion from the adrenal gland, resulting in increased renal tubular sodium reabsorption and concomitant secretion of potassium and hydrogen [1]. Renin plasma levels are useful in the diagnosis of hypertension. Plasma renin is reduced in patients with hypertension due to hyperaldosteronism, while both renin and aldosterone levels are elevated in patients with renovascular hypertension [2].
- Norman AW & Litwack G. Hormones. Academic Press, Inc., San Diego, 1987, pp 615-629.
- Cummins P. Heart IN: The Immunoassay Handbook. M Stockton Press, New York, 1994, pp433-440.
| |
|
 |
| Diagnostic Systems Laboratories, Inc. | | Customer Service: (800) 231-7970 | | Web site: http://www.dslabs.com | | Please mention Medcompare.com when you contact the vendor. |
| NOTE: Medcompare disclaims any information on this site. The information found on Medcompare (Drug Guide, Product Listings and otherwise) is intended for use by medical professionals. This information is not intended to replace the information, advice or instructions from a medical doctor. Pricing information is approximate, actual prices may vary. |
|
|
