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> > > SHBG IRMA Test

SHBG IRMA Test

General Information

Vendor		Diagnostic Systems Laboratories, Inc.
Item		SHBG IRMA Test
Features		Inquire
Approval		For In Vitro Diagnostic Use
Product Number		DSL-7400
Size		100 tubes
Range		6, 5 - 300 nmol/L
Sample Type		Serum
Sensitivity		3 nmol/L
Incubation Time		2 hrs on shaker at RT
Storage / Stability		8 wks
Sample Size		25 �L Diluted Samples
Pretreatment		1: 100 Dilution
Format / Method		Coated Tube IRMA
Pricing		Inquire

Product Description

Human sex hormone-binding globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bioavailability of sex steroids. SHBG is produced primarily in the liver. SHBG synthesis and release are regulated by a number of factors which lead to increased ( i.e. thyroid hormones, estrogens, stress, male aging, phenytoin, high carbohydrate intake) or decreased (i.e. obesity, testosterone, prolactin, growth hormone, female aging-menopause, progestins, glucocorticoids) serum levels [2]. Abnormal serum SHBG levels have been reported in a number of conditions, including obesity and female hyperandrogenism (including polycystic ovary disease) [1,2]. Serum SHBG levels are inversely related to free, presumably bioactive, testosterone concentrations, and as a result a free testosterone index based on the ratio of total testosterone to SHBG has been characterized [3,4].

Hammond GF. Endocrin Rev 11:65-79, 1990.
Rosner W. Endocrin Rev 11:80-91, 1990.
Mathur RS, et al. Fertil Steril 35:29-35, 1981.
Nanjee MN & Wheeler MJ. Ann Clin Biochem 22:387-390, 1985.

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