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	Laboratory Information Systems – Today’s Hot Topics & Technology

> > > Vasopressin (AVP) RIA Test

Vasopressin (AVP) RIA Test

General Information

Vendor		Diagnostic Systems Laboratories, Inc.
Item		Vasopressin (AVP) RIA Test
Approval		For In Vitro Diagnostic Use
Product Number		DSL-1800
Size		50 tubes
Range		1 - 64 pg/mL
Sample Type		Plasma, Urine
Sensitivity		0.5 pg/mL
Incubation Time		2 x 24 hrs at 4C + 30 mins at RT
Storage / Stability		8 wks
Sample Size		300 µL Extracted Samples
Pretreatment		Extraction of Plasma
Format / Method		Double Antibody RIA
Pricing		Inquire
Financing		To finance this purchase click here (U.S. customers only)

Product Description

Arginine vasopressin (AVP), also known as Antidiurectic Hormone (ADH), is synthesized in the hypothalamus and is transported via exonal flow to the posterior pituitary for storage and eventual release. AVP secretion is regulated by changes in blood osmolality and also by baroreceptors that respond to alterations in blood volume or arterial pressure. Non-osmotic stimuli include pain, stress, sleep and exercise [1]. The primary function of AVP is the regulation of water permeability of the renal collecting tubules and ascending loop of Henle. Mediated through activation of cAMP, the effect of AVP is to allow the kidney to reabsorb water and concentrate urine [1]. At high plasma concentrations, AVP induces a generalized vasoconstriction that leads to a rise in arterial blood pressure. A deficiency in AVP secretion or action is a characteristic of polyuria, a condition in which the renal tubules fail to reabsorb solute-free water. In contrast, sustained, elevated levels of AVP in the absence of any known stimuli are observed in syndrome of inappropriate antidiuretic hormone (SIADH) and can result from a number of factors including secretion of AVP by malignancy, disorders of the central nervous or pulmonary systems, or as a side effect to certain drug therapies.

Whitley RJ, et al. Endocrinology. IN Burtis CA & Ashwood ER (eds). Tietz Textbook of Clinical Chemistry, 2nd ed. WB Saunders Company, Philadelphia, 1994. ch 35, pg 1685-1689.

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