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Genetic Analysis Systems in the Clinical Mainstream
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> > > PR3-directed antibody EIA Kit

PR3-directed antibody EIA Kit

PR3-directed antibody EIA Kit
General Information
VendorIBL-America
ItemPR3-directed antibody EIA Kit
Catalog NumberORG 518
Size1 x 96
Regulatory Status510k Cleared
PricingInquire
Product Description
In 1982 antineutrophil antibodies have been first reported in a few patients suffering from necrotising glomerulonephritis. This lead to the discovery of immunodiagnostic extremely important autoantibodies, that are detected in systemic vasculitic disorders. Proteinase 3 is the classical autoantigen in Wegener's granulomatosis. About 2/3 of patients in the initial phase of the disease course exhibit Anti-PR3. During active phases Anti-PR3 can be detected in more than 95% of all patients. Anti-PR3 antibodies are directed against the lysosomal enzyme Proteinase 3 located in neutrophil granulocytes and monocytes.
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